If you’re a wireless mouse owner, probably have experienced a situation where mouse becomes irresponsive. We can try the following to make it right. If none of these works, contact your vendor for more assistance!
Try different USB port
Insert the device in another USB port. Try without USB extenders.
Re-Synchronize the receiver
Check for constant green light on the wireless transmitter/receiver after plugging in. Check the red light under mouse blinks well. Push the reset buttons on both mouse and receiver after connecting it to the power. Remove and insert if necessary. Most of the synchronization problems should be resolved by this step.

Image Taken from Microsoft.com
Remove and Insert batteries again
Remove the undercover and insert the battery again. Also ensure that it’s not a drained battery. Always use good quality batteries with your mouse.
Interference
There’s a chance that other wireless devices, mobile phones, radios etc. interfering wireless signals. Take required steps to avoid them.
Upgrade your software
Especially when working with old version of Windows, the latest drivers may not be available. Download it from product vendor’s website. Windows 7 and Vista support most of the latest hardware. Download the drivers from here, if you’re using Microsoft Wireless Mouse of Keyboard
Try This in different computer
Borrow your friend’s computer for a minute and check if it works!

I had one! now not using it…